(19)

(11)

EP 1 297 139 A2

(12)

(88) Date of publication A3: 11.04.2002 (43) Date of publication: 02.04.2003 Bulletin 2003/14 (21) Application number: 01960347.1 (22) Date of filing: 20.06.2001

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/72, C07K 16/28, G01N 33/50, G01N 33/566, C12Q 1/68, A61K 39/17, A61K 31/70, A61K 48/00 (86) International application number: PCT/EP0107/018 (87) International publication number: WO 0200/0725 (03.01.2002 Gazette 2002/01)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 26.06.2000 EP 00305379 (71) Applicant: Akzo Nobel N.V. 6824 BM Arnhem (NL)	(72) Inventors: GRASSIE, Morag, A. Glasgow G72 8NF (GB) GRANT, Emma, Jane Glasgow G20 6AF (GB) KLOMP, Johannes, Petrus, Gerardus NL-5066 GE Moergestel (NL) (74) Representative: van Wezenbeek, Petrus M.G.F.  N.V. OrganonP.O. Box 20 5340 BH Oss 5340 BH Oss (NL)