(19)
(11) EP 1 298 217 A8

(12) CORRECTED EUROPEAN PATENT APPLICATION
published in accordance with Art. 158(3) EPC

(48) Corrigendum issued on:
06.08.2003 Bulletin 2003/32

(43) Date of publication:
02.04.2003 Bulletin 2003/14

(21) Application number: 01949913.6

(22) Date of filing: 04.07.2001
(51) International Patent Classification (IPC)7: C12P 21/00, C12N 15/10, C07K 14/00
// C12P21:00, C12R1:91
(86) International application number:
PCT/JP0105/812
(87) International publication number:
WO 0200/2793 (10.01.2002 Gazette 2002/02)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 05.07.2000 JP 2000204327

(71) Applicants:
  • Japan as represented by Secretary of Osaka University
    Suita-shi, Osaka 565-0871 (JP)
  • Mitsubishi Pharma Corporation
    Osaka-shi, Osaka 541-0046 (JP)

(72) Inventors:
  • SUGA, Kenichi, c/o Graduate School of Engineering
    Suita-shi, Osaka 565-0871 (JP)
  • OMASA, Takeshi, c/o Graduate School of Engineering
    Suita-shi, Osaka 565-0871 (JP)
  • KISHIMOTO, Michimasa, c/o Graduate School of Eng.
    Suita-shi, Osaka565-0871 (JP)
  • KATAKURA, Yoshio, c/o Graduate School of Eng.
    Suita-shi, Osaka 565-0871 (JP)
  • OHDA, Toyoo, c/o Mitsubishi Pharma Corporation
    Chuo-ku, Tokyo 103-8405 (JP)
  • MIKI, Hideo,c/o Mitsubishi Pharma Corporation
    Chuo-ku, Tokyo 103-8405 (JP)
  • KOBAYASHI, Kaoru, Mitsubishi Pharma Corporation
    Chuo-ku, Tokyo 103-8405 (JP)

(74) Representative: Krauss, Jan 
Forrester & Boehmert, Pettenkoferstrasse 20-22
80336 München
80336 München (DE)

   


(54) PROCESS FOR PRODUCING GLYCOPROTEIN


(57) A means of controlling sugar chain-modification and sugar chain structure in the production of a glycoprotein with the use of gene recombination techniques. A process for producing a glycoprotein by culturing a gene recombinant host in a medium characterized in that the relative sugar consumption speed is employed as an indication and changed to thereby modify the sugar chain structure attached to the protein.