(19)

(11)

EP 1 299 116 A2

(12)

(88) Date of publication A3: 20.06.2002 (43) Date of publication: 09.04.2003 Bulletin 2003/15 (21) Application number: 01958283.2 (22) Date of filing: 12.07.2001

(51) International Patent Classification (IPC)7: A61K 39/106, C12N 1/20, A61P 31/04 // C12N15:31 (86) International application number: PCT/IB0101/536 (87) International publication number: WO 0200/7763 (31.01.2002 Gazette 2002/05)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 12.07.2000 GB 0017149 (71) Applicant: Chiron S.p.A. 53100 Siena (IT)	(72) Inventors: DEL GIUDICE, Guiseppe I-53100 Siena (IT) RAPPUOLI, Rino I-53100 Siena (IT) (74) Representative: Marshall, Cameron John et al Carpmaels & Ransford43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)