(19)

(11)

EP 1 299 407 A2

(12)

(88) Date of publication A3: 26.09.2002 (43) Date of publication: 09.04.2003 Bulletin 2003/15 (21) Application number: 01938984.0 (22) Date of filing: 23.05.2001

(51) International Patent Classification (IPC)7: C07H 21/04, C12P 21/00, C12N 5/14, C12N 15/82 (86) International application number: PCT/US0110/830 (87) International publication number: WO 0109/2465 (06.12.2001 Gazette 2001/49)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 25.05.2000 US 206984 P (71) Applicant: BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORPORATION Peoria, IL 61604 (US)	(72) Inventor: MUHITCH, Michael, J. Peoria, IL 61615 (US) (74) Representative: Schüssler, Andrea, Dr.  Kanzlei Huber & SchüsslerTruderinger Strasse 246 81825 München 81825 München (DE)