(19)

(11)

EP 1 299 527 A2

(12)

(88) Date of publication A3: 28.03.2002 (43) Date of publication: 09.04.2003 Bulletin 2003/15 (21) Application number: 01947090.5 (22) Date of filing: 28.06.2001

(51) International Patent Classification (IPC)7: C12N 9/10, C12N 1/21, C12Q 1/68, C12P 19/44, A61K 39/106, A61K 31/739, G01N 33/50 // (C12N1/21, C12R1:19, 1:01) (86) International application number: PCT/CA0100/969 (87) International publication number: WO 0200/0851 (03.01.2002 Gazette 2002/01)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 28.06.2000 WO PCT/CA00/00777 21.12.2000 US 257574 P (71) Applicant: NATIONAL RESEARCH COUNCIL OF CANADA Ottawa,Ontario N5V 4T3 (CA)	(72) Inventors: HIRATSUKA, Koji Stittsville, Ontario K2S 1C9 (CA) ALTMAN, Eleonora Gloucester, Ontario K1J 7X5 (CA) (74) Representative: Jackson, Derek Charles  Derek Jackson AssociatesThe Old YardLower Town ClainesWorcester WR3 7RY ClainesWorcester WR3 7RY (GB)