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(11)

EP 1 299 549 A1

(12)

(43) Date of publication: 09.04.2003 Bulletin 2003/15 (21) Application number: 01947091.3 (22) Date of filing: 28.06.2001

(51) International Patent Classification (IPC)7: C12N 15/54, C12N 9/10, C12N 15/63, C12N 1/21, C07K 16/40, C12Q 1/68, G01N 33/50, G01N 33/53, A61K 38/45, A61K 39/395, A61K 39/106, A61K 31/7088, C12P 19/18 // C12P19:18, C12R1:01 (86) International application number: PCT/CA0100/970 (87) International publication number: WO 0200/0888 (03.01.2002 Gazette 2002/01)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 28.06.2000 WO PCT/CA00/00777 21.12.2000 US 257692 P (71) Applicant: National Research Council of Canada Ottawa,Ontario K1A 0R6 (CA)	(72) Inventors: HIRATSUKA, Koji Stittsville, Ontario K2S 1C9 (CA) LOGAN, Susan M. Ottawa, Ontario K1K 0H1 (CA) (74) Representative: Jackson, Derek Charles  Derek Jackson AssociatesThe Old YardLower Town ClainesWorcester WR3 7RY ClainesWorcester WR3 7RY (GB)