(19)

(11)

EP 1 301 200 A2

(12)

(88) Date of publication A3: 18.07.2002 (43) Date of publication: 16.04.2003 Bulletin 2003/16 (21) Application number: 01941488.7 (22) Date of filing: 17.05.2001

(51) International Patent Classification (IPC)7: A61K 38/25, A61K 38/26, A61K 38/29, A61K 47/12, A61K 47/26 (86) International application number: PCT/US0115/872 (87) International publication number: WO 0108/7322 (22.11.2001 Gazette 2001/47)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 19.05.2000 US 205262 P (71) Applicant: BIONEBRASKA, INC. Lincoln, NE 68524 (US)	(72) Inventors: HOLMQUIST, Barton Lincoln, NE 68528 (US) DORMADY, Daniel, C. Omaha, NE 68164 (US) (74) Representative: Pohlman, Sandra M. et al Dörries Frank-Molnia & Pohlman,Triftstrasse 13 80538 München 80538 München (DE)