(19)

(11)

EP 1 301 465 A2

(12)

(88) Date of publication A3: 14.03.2002 (43) Date of publication: 16.04.2003 Bulletin 2003/16 (21) Application number: 01950647.6 (22) Date of filing: 29.06.2001

(51) International Patent Classification (IPC)7: C07C 237/26, A61K 31/65, C07C 231/12, A61P 31/04 (86) International application number: PCT/US0120/716 (87) International publication number: WO 0200/4405 (17.01.2002 Gazette 2002/03)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 07.07.2000 US 216580 P (71) Applicants: TRUSTEES OF TUFTS COLLEGE Medford, MA 02155 (US) Paratek Pharmaceuticals, Inc. Boston, MA 02111 (US)	(72) Inventors: NELSON, Mark, L. Wellesley, MA 02481 (US) MCINTYRE, Laura Cambridge, MA 02139 (US) RENNIE, Glen South Weymouth, MA 02190 (US) BHATIA, Beena Arlington, MA 02476 (US) (74) Representative: Nash, David Allan  Haseltine Lake & Co.,Imperial House, 15-19 Kingsway London WC2B 6UD London WC2B 6UD (GB)