(19)

(11)

EP 1 303 528 A1

(12)

(43) Date of publication: 23.04.2003 Bulletin 2003/17 (21) Application number: 00945940.5 (22) Date of filing: 12.07.2000

(51) International Patent Classification (IPC)7: C07H 19/16, A61K 31/70, A61P 3/06, A61P 3/10 (86) International application number: PCT/EP0006/958 (87) International publication number: WO 0200/4474 (17.01.2002 Gazette 2002/03)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: Nikken Chemicals Company, Limited Tokyo 104-0045 (JP)	(72) Inventors: WERMUTH, Camille-Georges F-67100 Strasbourg (FR) MANN, André F-67540 Ostwalt (FR) SCHOENFELDER, Angèle F-67450 Lampertheim (FR) KANAYA, S.Omiya Res. Lab.Nikken Chem. Co., Ltd. Saitama-shiSaitama 330-0835 (JP) (74) Representative: Cabinet Hirsch  34, Rue de Bassano 75008 Paris 75008 Paris (FR)