(19)

(11)

EP 1 305 048 A2

(12)

(88) Date of publication A3: 27.12.2002 (43) Date of publication: 02.05.2003 Bulletin 2003/18 (21) Application number: 01958373.1 (22) Date of filing: 31.07.2001

(51) International Patent Classification (IPC)7: A61K 45/06, A61P 31/00 (86) International application number: PCT/IN0100/139 (87) International publication number: WO 0200/9758 (07.02.2002 Gazette 2002/06)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.08.2000 US 222201 P 19.08.2000 US 640947 21.11.2000 WO PCT/IN00/00111 25.04.2001 US 286291 P 07.05.2001 US 850669 08.05.2001 WO PCT/IN01/00100 (71) Applicant: Wockhardt Limited Mumbai 400 051 (IN)

(72) Inventors: DE SOUZA, Noel, J.,c/o Wockhardt Research Centre Aurangabad 431 210 (IN) PATEL, Mahesh, V.,c/o Wockhardt Research Centre Aurangabad 431 210 (IN) GUPTE, Shrikant, V.,c/o Wockhardt Research Centre Aurangabad 431 210 (IN) UPADHYAY, Dilip, J.,c/o Wockhardt Research Centre Aurangabad 431 210 (IN) SHUKLA, Milind, C.,c/o Wockhardt Research Centre Aurangabad 431 210 (IN) CHATURVEDI, Nishith, C.,c/o Wockhardt Res. Centre Aurangabad 431 210 (IN) BHAWSAR, Satish, B.,c/o Wockhardt Research Centre Aurangabad 431 210 (IN) NAIR, Sheela, C.,c/o Wockhardt Research Centre Aurangabad 431 210 (IN) JAFRI, Mohammed, A.,c/o Wockhardt Research Centre Aurangabad 431 210 (IN) (74) Representative: Ebner von Eschenbach, Jennifer et al Ladas & Parry,Dachauerstrasse 37 80335 München 80335 München (DE)