(19)
(11) EP 1 305 401 A2

(12)

(88) Date of publication A3:
18.07.2002

(43) Date of publication:
02.05.2003 Bulletin 2003/18

(21) Application number: 01969324.1

(22) Date of filing: 28.06.2001
(51) International Patent Classification (IPC)7: C12N 5/06, A01K 67/027
(86) International application number:
PCT/EP0107/396
(87) International publication number:
WO 0200/0847 (03.01.2002 Gazette 2002/01)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 28.06.2000 EP 00202254
31.07.2000 US 628883

(71) Applicant: Thromb-X N.V.
3000 Leuven (BE)

(72) Inventors:
  • SCHOONJANS, Luc
    B-3012 Wilsele (BE)
  • MOREADITH, Randall
    Chapel Hill, NC 27514 (US)

(74) Representative: Van Someren, Petronella F. H. M. 
Arnold & Siedsma,Sweelinkplein 1
2517 GK The Hague
2517 GK The Hague (NL)

   


(54) PLURIPOTENT EMBRYONIC STEM (ES) CELL LINES, IMPROVED METHODS FOR THEIR PRODUCTION, AND THEIR USE FOR GERM LINE TRANSMISSION AND FOR THE GENERATION OF GENETICALLY MODIFIED ANIMALS