(19)

(11)

EP 1 305 414 A2

(12)

(88) Date of publication A3: 19.09.2002 (43) Date of publication: 02.05.2003 Bulletin 2003/18 (21) Application number: 01956237.0 (22) Date of filing: 27.07.2001

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/86, C12N 7/01, C12N 5/10, C07K 14/705, A61K 38/17, A61K 48/00 (86) International application number: PCT/CA0101/092 (87) International publication number: WO 0201/0379 (07.02.2002 Gazette 2002/06)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 31.07.2000 US 222043 P (71) Applicants: Aventis Pasteur Limited Toronto,Ontario M2R 3T4 (CA) Therion Biologics Cambridge, MA 02142 (US) National Cancer Institute Rockville, MD 20852 (US)	(72) Inventors: BERINSTEIN, Neil Toronto, Ontario M5P 1V1 (CA) TARTAGLIA, James Schenectady, NY 12303 (US) TINE, John, A. Scotia, NY 12302 (US) PANICALI, Dennis, L. Cambridge, MA 02142 (US) GRITZ, Linda Cambridge, MA 02142 (US) SCHLOM, Jeffrey Potomac, MD 20854 (US) (74) Representative: Nachshen, Neil Jacob et al D Young & Co21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)