(19)

(11)

EP 1 305 446 A1

(12)

(43) Date of publication: 02.05.2003 Bulletin 2003/18 (21) Application number: 01959167.6 (22) Date of filing: 25.07.2001

(51) International Patent Classification (IPC)7: C12Q 1/68, C07H 21/02, C07H 21/04, C12N 15/00 (86) International application number: PCT/US0123/321 (87) International publication number: WO 0200/8467 (31.01.2002 Gazette 2002/05)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 25.07.2000 US 220662 P (71) Applicant: DZ Genes LLC Richmond Heights, MO 63117 (US)	(72) Inventor: MOSKOWITZ, David, W. St. Louis, MO 63132 (US) (74) Representative: Smaggasgale, Gillian Helen  W.P. Thompson & Co,Celcon House,289-293 High Holborn London WC1V 7HU London WC1V 7HU (GB)