(19)

(11)

EP 1 307 461 A2

(12)

(88) Date of publication A3: 18.07.2002 (43) Date of publication: 07.05.2003 Bulletin 2003/19 (21) Application number: 01958850.8 (22) Date of filing: 20.07.2001

(51) International Patent Classification (IPC)7: C07D 495/04, A61K 31/407, A61P 29/00 // (C07D495/04, 333:00), C07D209:00 (86) International application number: PCT/US0121/106 (87) International publication number: WO 0201/2249 (14.02.2002 Gazette 2002/07)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 04.08.2000 US 223398 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, IN 46285 (US)	(72) Inventors: BEIGHT, Douglas, Wade Frankfort, IN 46041 (US) MORIN, John, Michael, Junior Brownsburg, IN 46112 (US) SAWYER, Jason, Scott Indianapolis, IN 46220 (US) SMITH, Edward, C., R. Fishers, IN 46038 (US) (74) Representative: Kingsbury, Oliver William  Eli Lilly and Company Limited,Erl Wood Manor,Sunninghill Road Windlesham, Surrey GU20 6PH Windlesham, Surrey GU20 6PH (GB)