(19)

(11)

EP 1 307 546 A2

(12)

(88) Date of publication A3: 19.09.2002 (43) Date of publication: 07.05.2003 Bulletin 2003/19 (21) Application number: 01957656.0 (22) Date of filing: 02.08.2001

(51) International Patent Classification (IPC)7: C12N 9/12 (86) International application number: PCT/CA0101/109 (87) International publication number: WO 0201/2456 (14.02.2002 Gazette 2002/07)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 03.08.2000 US 222650 P 12.03.2001 US 274613 P 28.03.2001 CA 2340783 (71) Applicant: 1149336 ONTARIO INC. Toronto,Ontario M6B 3G3 (CA)	(72) Inventors: DRUCKER, Daniel, J. Toronto, Ontario M6B 3G3 (CA) ROSEN, Cheryl, F. Toronto, Ontario M6B 3G3 (CA) LEFEBVRE, Diana, L. Mississauga, Ontario L5N 5N6 (CA) (74) Representative: Chapman, Paul Gilmour et al Cruikshank & Fairweather,19 Royal Exchange Square Glasgow G1 3AE Glasgow G1 3AE (GB)