(19)

(11)

EP 1 307 548 A2

(12)

(88) Date of publication A3: 17.10.2002 (43) Date of publication: 07.05.2003 Bulletin 2003/19 (21) Application number: 01957149.6 (22) Date of filing: 13.07.2001

(51) International Patent Classification (IPC)7: C12N 15/00, C12N 9/00 (86) International application number: PCT/US0122/160 (87) International publication number: WO 0200/6457 (24.01.2002 Gazette 2002/04)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 13.07.2000 US 217954 P 21.06.2001 US 300378 P (71) Applicant: Maxygen, Inc. Redwood City, CA 94063 (US)	(72) Inventors: GIVER, Lorraine, J. Santa Clara, CA 95051 (US) MINSHULL, Jeremy Menlo Park, CA 94025 (US) VOGEL, Kurt Palo Alto, CA 94306 (US) (74) Representative: Ryberg, Lise Abildgaard et al Maxygen ApS,Agern Alle 1 2970 Hoersholm 2970 Hoersholm (DK)