(19)

(11)

EP 1 309 332 A2

(12)

(88) Date of publication A3: 13.06.2002 (43) Date of publication: 14.05.2003 Bulletin 2003/20 (21) Application number: 01962298.4 (22) Date of filing: 10.07.2001

(51) International Patent Classification (IPC)7: A61K 31/7048, A61K 9/00 (86) International application number: PCT/US0141/328 (87) International publication number: WO 0200/3998 (17.01.2002 Gazette 2002/03)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.07.2000 US 217032 P (71) Applicant: CHIRON CORPORATION EmeryvilleCalifornia 94608-2916 (US)	(72) Inventors: BAKER, William, R. Bellevue, WA 98006 (US) CHALLONER, Peter, B. Seattle, WA 98109 (US) SHAWAR, Ribhi, M. Bellevue, WA 98006 (US) HUH, KAY, K. Bellevue, WA 98004 (US) RYCMAN, David, M. Bellevue, WA 98006 (US) (74) Representative: Hallybone, Huw George et al Carpmaels and Ransford,43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)