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(11)

EP 1 309 551 A1

(12)

(43) Date of publication: 14.05.2003 Bulletin 2003/20 (21) Application number: 01976067.7 (22) Date of filing: 09.08.2001

(51) International Patent Classification (IPC)7: C07D 209/08, C07D 401/12, C07D 403/12, C07D 403/14, C07D 413/12, C07D 417/12, C07D 493/10, A61K 31/4453, A61K 31/496, A61K 31/5377 // (C07D493/10, 317:00), C07D221:00,(C07D493/10, 319:00), C07D221:00 (86) International application number: PCT/EP0109/273 (87) International publication number: WO 0201/4273 (21.02.2002 Gazette 2002/08)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 12.08.2000 GB 0019950 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford,Middlesex TW8 9GS (GB)

(72) Inventors: BROMIDGE, Steven, MarkGlaxoSmithKline Pharm. Harlow,Essex CM19 5AW (GB) LOVELL, Peter, JohnGlaxoSmithKline Pharm. Harlow,Essex CM19 5AW (GB) MOSS, Stephen, FrederickGlaxoSmithKline Pharm. Harlow,Essex CM19 5AW (GB) SERAFINOWSKA, Halina,TeresaGlaxoSmithKline Pharm. Harlo w,Essex CM19 5AW (GB) (74) Representative: Kondo, Rie  GlaxoSmithKline,CIP,CN925.1,980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)