(19)

(11)

EP 1 309 608 A2

(12)

(88) Date of publication A3: 03.01.2003 (43) Date of publication: 14.05.2003 Bulletin 2003/20 (21) Application number: 01912809.9 (22) Date of filing: 15.02.2001

(51) International Patent Classification (IPC)7: C07K 5/00, A61K 38/00, A01H 11/00, A01H 5/00 (86) International application number: PCT/US0105/241 (87) International publication number: WO 0106/0972 (23.08.2001 Gazette 2001/34)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 15.02.2000 US 183073 P 15.02.2000 US 183089 P (71) Applicant: Washington State University Research Foundation Pullman, WA 99164-1802 (US)	(72) Inventors: RYAN, Clarence, A. Pullman, WA 99163-4607 (US) PEARCE, Gregory, L. Palouse, WA 99161 (US) SCHERER, DE MOURA, Daniel Pullman, WA 99163 (US) (74) Representative: Cornish, Kristina Victoria Joy et al Kilburn & Strode,20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)