(19)

(11)

EP 1 311 280 A2

(12)

(88) Date of publication A3: 11.04.2002 (43) Date of publication: 21.05.2003 Bulletin 2003/21 (21) Application number: 01956077.0 (22) Date of filing: 01.08.2001

(51) International Patent Classification (IPC)7: A61K 38/03, C07K 2/00, C07K 19/00 (86) International application number: PCT/US0124/088 (87) International publication number: WO 0200/9649 (07.02.2002 Gazette 2002/06)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.08.2000 US 629719 (71) Applicant: THE UNIVERSITY OF KANSAS Lawrence,KS 66045 (US)	(72) Inventors: SIAHAAN, Teruna, J. Lawrence, KS 66047 (US) YUSUF-MAKAGIANSAR, Helena Lawrence, KS 66049 (US) ANDERSON, Meagan Olathe, Kansas (US) XU, Rong, Christine Lawrence, KS 66046 (US) (74) Representative: UEXKÜLL & STOLBERG  PatentanwälteBeselerstrasse 4 22607 Hamburg 22607 Hamburg (DE)