(19)

(11)

EP 1 311 302 A2

(12)

(88) Date of publication A3: 27.02.2003 (43) Date of publication: 21.05.2003 Bulletin 2003/21 (21) Application number: 01946697.8 (22) Date of filing: 21.06.2001

(51) International Patent Classification (IPC)7: A61K 51/08, A61K 41/00 (86) International application number: PCT/US0120/108 (87) International publication number: WO 0109/7860 (27.12.2001 Gazette 2001/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.06.2000 US 213206 P (71) Applicant: Bristol-Myers Squibb Pharma Company Wilmington,Delaware 19805 (US)

(72) Inventors: RAJOPADHYE, Milind Westford, MA 01886 (US) EDWARDS, D., Scott Burlington, MA 01803 (US) BARRETT, John, A. Groton, MA 01450 (US) CARPENTER, Alan, P., Jr. Carlisle, MA 01741 (US) HEMINWAY, Stuart, J. Arlington, MA 02474 (US) LIU, Shuang Chelmsford, AK 01824 (US) SINGH, Prahlad Arlington, MA 02474 (US) (74) Representative: Howard, Paul Nicholas  Carpmaels & Ransford43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)