(19)
(11) EP 1 311 662 A2

(12)

(88) Date of publication A3:
16.01.2003

(43) Date of publication:
21.05.2003 Bulletin 2003/21

(21) Application number: 01964006.9

(22) Date of filing: 14.08.2001
(51) International Patent Classification (IPC)7: C12N 15/00, C07K 16/30, A61K 47/48
(86) International application number:
PCT/US0125/464
(87) International publication number:
WO 0201/6581 (28.02.2002 Gazette 2002/09)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 24.08.2000 WO PCT/US00/23328
28.02.2001 WO PCT/US01/06520
22.06.2001 US 888257
22.06.2001 WO PCT/US01/20118

(71) Applicant: Genentech, Inc.
South San Francisco, CA 94080-4990 (US)

(72) Inventors:
  • GAO, Wei-Qiang
    Foster City, CA 94404 (US)
  • POLAKIS, Paul
    Burlingame, CA 94010 (US)
  • SHOU, Jianyong
    Fremont, CA 94538 (US)
  • SMITH, Victoria
    Burlingame, CA 94010 (US)
  • SORIANO, Robert
    San Francisco, CA 94103 (US)
  • WILLIAMS, P. Mickey
    Half Moon Bay, CA 94019 (US)
  • WU, Thomas D.
    San Francisco, CA 94110 (US)
  • ZHANG, Zemin
    Foster City, CA 94404 (US)

(74) Representative: Denison, Christopher Marcus et al
Mewburn EllisYork House23 Kingsway
London WC2B 6HP
London WC2B 6HP (GB)

   


(54) COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR