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(11)

EP 1 311 812 A1

(12)

(43) Date of publication: 21.05.2003 Bulletin 2003/21 (21) Application number: 01909180.0 (22) Date of filing: 12.02.2001

(51) International Patent Classification (IPC)7: G01J 3/44, G01N 21/64 (86) International application number: PCT/US0104/582 (87) International publication number: WO 0201/6895 (28.02.2002 Gazette 2002/09)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 18.08.2000 WO PCT/US00/22754 (71) Applicant: Washington State University Research Foundation Pullman, WA 99164-1802 (US)	(72) Inventors: KRAMER, David, M. Pullman, WA 99163 (US) SACKSTEDER, Colette, A. St. Paul, MN 55117 (US) (74) Representative: Ford, Timothy James et al Kilburn & Strode20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)