| (19) |
 |
|
(11) |
EP 1 312 366 A8 |
| (12) |
CORRECTED EUROPEAN PATENT APPLICATION |
|
published in accordance with Art. 158(3) EPC |
| (48) |
Corrigendum issued on: |
|
12.11.2003 Bulletin 2003/46 |
| (43) |
Date of publication: |
|
21.05.2003 Bulletin 2003/21 |
| (22) |
Date of filing: 08.08.2001 |
|
| (86) |
International application number: |
|
PCT/JP0106/805 |
| (87) |
International publication number: |
|
WO 0201/1734 (14.02.2002 Gazette 2002/07) |
|
| (84) |
Designated Contracting States: |
|
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
Designated Extension States: |
|
AL LT LV MK RO SI |
| (30) |
Priority: |
08.08.2000 JP 2000240455
|
| (71) |
Applicant: Wakamoto Pharmaceutical Co., Ltd. |
|
Chuo-ku, Tokyo 103-8330 (JP) |
|
| (72) |
Inventors: |
|
- SUZUKI, Hidekazu, c/o WAKAMOTO PHARM. CO., LTD.
Chuo-ku, Tokyo 103-8330 (JP)
- WADA, Takahiro, c/o WAKAMOTO PHARM. CO., LTD.
Chuo-ku, Tokyo 103-8330 (JP)
- KIRITA, Masanobu
Kashiwa-shi, Chiba 277-0084 (JP)
- TAKEUCHI, Masanobu, c/o WAKAMOTO PHARM. CO., LTD.
Chuo-ku, Tokyo 103-8330 (JP)
|
|
| |
|
| (54) |
AQUEOUS PHARMACEUTICAL COMPOSITIONS |
(57) The present invention has an object to provide an antibacterial aqueous pharmaceutical
composition and an aqueous pharmaceutical composition which have a sufficiently low
gelation temperature even when new quinolone antibacterial agents such as ofloxacin
as the active ingredient and can be retained at the administration site for a long
time by virtue of rapid viscosity increase after administration in spite of their
being liquid at administration, thereby attaining high availability of a pharmaceutical
agent.
The present invention relates to an antibacterial aqueous pharmaceutical composition
which comprises: 2.8 to 4 w/v% of methylcellulose, the 2 w/v% aqueous solution
of which has a viscosity of 12 mPa·s or below at 20°C; 1.5 to 2.3 w/v% of citric acid;
2 to 4 w/v% of polyethylene glycol; and 0.1 to 0.5 w/v% of ofloxacin.