(19)

(11)

EP 1 313 506 A1

(12)

(43) Date of publication: 28.05.2003 Bulletin 2003/22 (21) Application number: 00959362.5 (22) Date of filing: 24.08.2000

(51) International Patent Classification (IPC)7: A61K 39/40, A61P 31/04, A61K 7/16 // (C07K16/12, 16:00) (86) International application number: PCT/US0023/277 (87) International publication number: WO 0201/5931 (28.02.2002 Gazette 2002/09)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (71) Applicants: Washington Dental Service Seattle, WA 98115 (US) The Regents of The University of California Oakland, CA 94607-5200 (US)	(72) Inventors: SHI, Wenyuan Los Angeles, CA 90045 (US) ANDERSON, Maxwell, H. Seattle, WA 98103 (US) (74) Representative: Cornish, Kristina Victoria Joy et al Kilburn & Strode,20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)