(19)

(11)

EP 1 313 719 A2

(12)

(88) Date of publication A3: 30.05.2002 (43) Date of publication: 28.05.2003 Bulletin 2003/22 (21) Application number: 01958860.7 (22) Date of filing: 27.07.2001

(51) International Patent Classification (IPC)7: C07D 277/68, A61K 31/395, A61P 43/00, C07D 263/58, C07D 209/34, C07D 215/22, C07D 233/26 (86) International application number: PCT/US0121/122 (87) International publication number: WO 0201/4275 (21.02.2002 Gazette 2002/08)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 11.08.2000 US 224497 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)

(72) Inventors: FORMAN, Scott Louis Indianapolis, IN 46250 (US) JONES, Winton, Dennis Carmel, IN 46033 (US) SMITH, Daryl, Lynn Fishers, IN 46038 (US) ZARRINMAYEH, Hamideh Carmel, IN 46032 (US) ZIMMERMAN, Dennis, Michael Zionsville, IN 46077 (US) (74) Representative: Kingsbury, Oliver William  Eli Lilly and Company Limited,Erl Wood Manor,Sunninghill Road Windlesham, Surrey GU20 6PH Windlesham, Surrey GU20 6PH (GB)