(19)

(11)

EP 1 315 476 A2

(12)

(88) Date of publication A3: 27.03.2003 (43) Date of publication: 04.06.2003 Bulletin 2003/23 (21) Application number: 01968448.9 (22) Date of filing: 04.09.2001

(51) International Patent Classification (IPC)7: A61K 9/00 (86) International application number: PCT/US0127/414 (87) International publication number: WO 0201/7880 (07.03.2002 Gazette 2002/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.09.2000 US 653406 (71) Applicant: Rice University Houston, TX 77005 (US)	(72) Inventors: HILL-WEST, Jennifer, L. Pearland, TX 77584 (US) MASTERS, Kristyn, Simcha Houston, TX 77025 (US) (74) Representative: Thomas, Philip John Duval  Eric Potter Clarkson,Park View House,58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)