(19)

(11)

EP 1 315 689 A1

(12)

(43) Date of publication: 04.06.2003 Bulletin 2003/23 (21) Application number: 01952111.1 (22) Date of filing: 30.04.2001

(51) International Patent Classification (IPC)7: C07B 59/00, C07C 19/08 // C07M5:00 (86) International application number: PCT/US0113/743 (87) International publication number: WO 0202/0434 (14.03.2002 Gazette 2002/11)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 07.09.2000 US 230780 P (71) Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION MadisonWisconsin 53707-7365 (US)	(72) Inventors: ROBERTS, Andrew, D. Madison, WI 53705 (US) NICKLES, Robert, J. Madison, WI 53705 (US) (74) Representative: McCluskie, Gail Wilson  J.A. Kemp & Co.,14 South Square,Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)