(19)
(11) EP 1 315 831 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
01.09.2010 Bulletin 2010/35

(45) Mention of the grant of the patent:
28.07.2010 Bulletin 2010/30

(21) Application number: 01920143.3

(22) Date of filing: 23.02.2001
(51) International Patent Classification (IPC): 
C12Q 1/26(2006.01)
(86) International application number:
PCT/US2001/005855
(87) International publication number:
WO 2001/062954 (30.08.2001 Gazette 2001/35)

(54)

STEAROYL-COA DESATURASE TO IDENTIFY TRIGLYCERIDE REDUCING THERAPEUTIC AGENTS

STEAROYL-COA-DESATURASE ZUR IDENTIFIZIERUNG VON TRIGLYCERIDREDUKTIONSTHERAPEUTIKA

METHODES ET COMPOSITIONS UTILISANT LA STEAROYL-COA DESATURASE POUR IDENTIFIER DES AGENTS THERAPEUTIQUES REDUISANT LES TRIGLYCERIDES

(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

(30) Priority: 24.02.2000 US 184526 P
31.07.2000 US 221697 P
15.12.2000 US 255771 P

(43) Date of publication of application:
04.06.2003 Bulletin 2003/23

(60) Divisional application:
09014795.0 / 2172560

(73) Proprietors:
  • Xenon Pharmaceuticals Inc.
    Burnaby, BC V5G 4W8 (CA)
  • Wisconsin Alumni Research Foundation
    Madison, WI 53726 (US)

(72) Inventors:
  • BROWNLIE, Alison, J.
    Vancouver, British Columbia V6R 2B6 (CA)
  • HAYDEN, Michael, R.
    Vancouver, British Columbia V6R 1W9 (CA)
  • ATTIE, Alan, D.
    Madison, WI 53711 (US)
  • NTAMBI, James, M.
    Madison, WI 53705 (US)
  • GRAY-KELLER, Mark, P.
    Middleton, WI 53562 (US)
  • MIYAZAKI, Makoto
    Madison, WI (US)

(74) Representative: LOUIS, PÖHLAU, LOHRENTZ 
Patentanwälte Postfach 30 55
90014 Nürnberg
90014 Nürnberg (DE)


(56) References cited: : 
US-A- 5 336 496
   
  • WATERS ET AL.: "Localization of a negative thyroid hormone-response region in hepatic stearoyl-CoA desaturase gene 1" BIOCHEM. BIOPHYS RES. COMM., vol. 233, 1997, pages 838-843, XP002209765
  • ZHANG ET AL.: "Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites" BIOCHEM. J., vol. 340, 1999, pages 255-264, XP000910887
  • DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1996 WATERS & NTAMBI: "Polyunsaturated fatty acids inhibit hepatic stearoyl-CoA desaturase-1 gene in diabetic mice." Database accession no. PREV199698795704 XP002209768 & LIPIDS, vol. 31, no. SUPPL., 1996, pages S33-S36, ISSN: 0024-4201
  • KUREBAYASHI S ET AL: "THIAZOLIDINEDIONES DOWNREGULATE STEAROYL-COA DESATURASE 1 GENE EXPRESSION IN 3T3-L1 ADIPOCYTES" DIABETES, NEW YORK, NY, US, vol. 46, December 1997 (1997-12), pages 2115-2118, XP002924128 ISSN: 0012-1797
  • SINGH & NTAMBI: "Nuclear factor 1 is essential fir the expression of stearoyl-CoA desaturase 1 gene during preadipocyte differentiation" BIOCHIM. BIOPHYS. ACTA, vol. 1398, 1998, pages 148-156, XP002209766
  • SESSLER ET AL.: "Regulation of stearoyl-CoA desaturase 1 mRNA stability by polyunsaturated fatty acids in 3T3-L1 adipocytes" J. BIOL. CHEM., vol. 271, no. 47, 22 November 1996 (1996-11-22), pages 29854-29858, XP001094092
  • NTAMBI: "Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol" J. LIPID RES., vol. 40, 1999, pages 1549-1558, XP001097612
  • PARK ET AL.: "Lipid level and type alter stearoyl CoA desaturase mRNA abundance differently in mice with distinct susceptibilities to diet-influenced diseases" J. NUTR., vol. 127, 1997, pages 566-573, XP002209767
  • SEIFRIED H.E.; GAYLOR J.L.: 'Investigatin of microsomal oxygenases of biosynthetic processes' J. BIOL. CHEM. vol. 251, 10 December 1976, pages 7468 - 7473
  • MIYAZAKI ET AL: 'The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearyl-CoA desaturase 1' J. BIOL. CHEM. vol. 275, 29 September 2000, pages 30132 - 30138
   
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