ATBECHDEDKESFRGBGRITLILUNLSEMCPTIE......FI....CY..TR................................................*JDIM360 Ver 2.15 (14 Jul 2008) - 2999001/01315831CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120100901W173deBibliographieenBibliographyfrBibliographieEP01920143.3200102232002081720040810enenen184526 P20000224US221697 P20000731US255771 P20001215US2010090120103520030604200323201007282010302010020120100901201035C12Q 1/26 20060101AFI20030414BHEP deSTEAROYL-COA-DESATURASE ZUR IDENTIFIZIERUNG VON TRIGLYCERIDREDUKTIONSTHERAPEUTIKAenSTEAROYL-COA DESATURASE TO IDENTIFY TRIGLYCERIDE REDUCING THERAPEUTIC AGENTSfrMETHODES ET COMPOSITIONS UTILISANT LA STEAROYL-COA DESATURASE POUR IDENTIFIER DES AGENTS THERAPEUTIQUES REDUISANT LES TRIGLYCERIDESUS-A- 5 336 496WATERS ET AL.: "Localization of a negative thyroid hormone-response region in hepatic stearoyl-CoA desaturase gene 1" BIOCHEM. BIOPHYS RES. COMM., vol. 233, 1997, pages 838-843, XP002209765ZHANG ET AL.: "Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites" BIOCHEM. J., vol. 340, 1999, pages 255-264, XP000910887DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1996 WATERS & NTAMBI: "Polyunsaturated fatty acids inhibit hepatic stearoyl-CoA desaturase-1 gene in diabetic mice." Database accession no. PREV199698795704 XP002209768 & LIPIDS, vol. 31, no. SUPPL., 1996, pages S33-S36, ISSN: 0024-4201KUREBAYASHI S ET AL: "THIAZOLIDINEDIONES DOWNREGULATE STEAROYL-COA DESATURASE 1 GENE EXPRESSION IN 3T3-L1 ADIPOCYTES" DIABETES, NEW YORK, NY, US, vol. 46, December 1997 (1997-12), pages 2115-2118, XP002924128 ISSN: 0012-1797SINGH & NTAMBI: "Nuclear factor 1 is essential fir the expression of stearoyl-CoA desaturase 1 gene during preadipocyte differentiation" BIOCHIM. BIOPHYS. ACTA, vol. 1398, 1998, pages 148-156, XP002209766SESSLER ET AL.: "Regulation of stearoyl-CoA desaturase 1 mRNA stability by polyunsaturated fatty acids in 3T3-L1 adipocytes" J. BIOL. CHEM., vol. 271, no. 47, 22 November 1996 (1996-11-22), pages 29854-29858, XP001094092NTAMBI: "Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol" J. LIPID RES., vol. 40, 1999, pages 1549-1558, XP001097612PARK ET AL.: "Lipid level and type alter stearoyl CoA desaturase mRNA abundance differently in mice with distinct susceptibilities to diet-influenced diseases" J. NUTR., vol. 127, 1997, pages 566-573, XP002209767SEIFRIED H.E.; GAYLOR J.L.: 'Investigatin of microsomal oxygenases of biosynthetic processes' J. BIOL. CHEM. vol. 251, 10 December 1976, pages 7468 - 7473MIYAZAKI ET AL: 'The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearyl-CoA desaturase 1' J. BIOL. CHEM. vol. 275, 29 September 2000, pages 30132 - 3013809014795.0217256020091127BROWNLIE, Alison, J.5320 West Broadway, Apartment 101Vancouver, British Columbia V6R 2B6CAHAYDEN, Michael, R.4484 West 7th AvenueVancouver, British Columbia V6R 1W9CAATTIE, Alan, D.1906 Vilas AvenueMadison, WI 53711USNTAMBI, James, M.4730 Waukesha StreetMadison, WI 53705USGRAY-KELLER, Mark, P.4558 Stonewood DriveMiddleton, WI 53562USMIYAZAKI, Makoto4801 Sheboygan AvenueMadison, WIUSXenon Pharmaceuticals Inc.10025666144015ep/hs3650 Gilmore WayBurnaby, BC V5G 4W8CAWisconsin Alumni Research Foundation10100988044015ep/hs614 Walnut Street, 13th FloorMadison, WI 53726USLOUIS, PÖHLAU, LOHRENTZ100060236Patentanwälte Postfach 30 5590014 NürnbergDEATBECHCYDEDKESFIFRGBGRIEITLILUMCNLPTSETRUS200100585520010223enWO200106295420010830200135