(19)

(11)

EP 1 317 288 A2

(12)

(88) Date of publication A3: 08.08.2002 (43) Date of publication: 11.06.2003 Bulletin 2003/24 (21) Application number: 01970744.7 (22) Date of filing: 10.09.2001

(51) International Patent Classification (IPC)7: A61K 48/00, A61P 35/00 (86) International application number: PCT/US0128/259 (87) International publication number: WO 0202/2175 (21.03.2002 Gazette 2002/12)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 11.09.2000 US 658779 (71) Applicant: MUSC Foundation For Research Development Charleston, SC 29425 (US)	(72) Inventors: DONG, Jian-Yun Mount Pleasant, SC 29466 (US) NORRIS, James, S. Mount Pleasant, SC 29464 (US) (74) Representative: Maschio, Antonio  D Young & Co,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)