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(11)

EP 1 317 433 A2

(12)

(88) Date of publication A3: 20.06.2002 (43) Date of publication: 11.06.2003 Bulletin 2003/24 (21) Application number: 01975734.3 (22) Date of filing: 06.09.2001

(51) International Patent Classification (IPC)7: C07D 239/42, C07D 401/12, C07D 405/12, C07D 403/12, C07D 405/14, C07D 413/14, C07D 401/14, C07D 213/85, C07D 213/75, C07D 213/74, C07D 213/80, A61K 31/505, A61P 25/28 (86) International application number: PCT/US0142/081 (87) International publication number: WO 0202/0495 (14.03.2002 Gazette 2002/11)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 06.09.2000 US 230480 P (71) Applicant: CHIRON CORPORATION EmeryvilleCalifornia 94608-2916 (US)

(72) Inventors: NUSS, John, M. Danville, CA 94506 (US) HARRISON, Stephen, D. Berkeley, CA 94702 (US) RING, David, B. Palo Alto, CA 94301 (US) BOYCE, Rustum, S. San Francisco, CA 94109 (US) JOHNSON, Kirk Moraga, CA 94556 (US) PFISTER, Keith, B. San Ramon, CA 94583 (US) RAMURTHY, Savithri Walnut Creek, CA 94596 (US) SEELY, Lynn Burlingame, CA 94010 (US) WAGMAN, Allan, S. Oakland, CA 94605 (US) DESAI, Manoj Pleasant Hill, CA 94523 (US) LEVINE, Barry, H. Lafayette, CA 94549 (US) (74) Representative: Hallybone, Huw George et al Carpmaels and Ransford,43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)