(19)
(11) EP 1 319 719 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
27.08.2008 Bulletin 2008/35

(45) Mention of the grant of the patent:
18.04.2007 Bulletin 2007/16

(21) Application number: 02026712.6

(22) Date of filing: 30.11.2002
(51) International Patent Classification (IPC): 
C12Q 1/68(2006.01)
 C12N 9/99(2006.01)

(54)

Reversibly modified thermostable enzymes for DNA synthesis and amplification in vitro

Reversibel modifizierte thermostabile Enzyme für die in vitro-Synthese und -Amplifizierung von DNA

Enzymes thermostables modifiées réversiblement pour la synthèse et l'amplification d'ADN in vitro

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

(30) Priority: 03.12.2001 EP 01128725

(43) Date of publication of application:
18.06.2003 Bulletin 2003/25

(73) Proprietors:
  • Roche Diagnostics GmbH
    68305 Mannheim (DE)
    Designated Contracting States:
    DE 
  • F. Hoffmann-La Roche AG
    4070 Basel (CH)
    Designated Contracting States:
    AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR 

(72) Inventors:
  • Sobek, Harald, Dr.
    82377 Penzberg (DE)
  • Greif, Michael
    83661 Lenggries (DE)

(74) Representative: Jung, Michael 
Roche Diagnostics GmbH Patentabteilung
68298 Mannheim
68298 Mannheim (DE)


(56) References cited: : 
EP-A- 1 088 891
WO-A-01/25483
US-A- 5 436 149
US-B1- 6 410 277
 EP-A- 1 130 118
US-A- 5 338 671
US-A- 5 773 258
   
  • KLENK ET AL: "Archaeoglobus fulgidus section 144 of 172 of the complete genome" EMBL NUCLEOTIDE SEQU, XP002130948
  • KLENK H-P ET AL: "The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus" NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 390, 27 November 1997 (1997-11-27), pages 364-370, XP002091622 ISSN: 0028-0836
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).