(19)
(11) EP 1 320 621 A2

(12)

(88) Date of publication A3:
02.05.2002

(43) Date of publication:
25.06.2003 Bulletin 2003/26

(21) Application number: 01975214.6

(22) Date of filing: 14.09.2001
(51) International Patent Classification (IPC)7: C12N 15/86
(86) International application number:
PCT/US0128/861
(87) International publication number:
WO 0202/2080 (21.03.2002 Gazette 2002/12)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 15.09.2000 US 233180 P

(71) Applicant: Merck & Co., Inc.
Rahway,New Jersey 07065-0907 (US)

(72) Inventors:
  • EMINI, Emilio, A.
    Rahway, NJ 07065-0907 (US)
  • YOUIL, Rima
    Rahway, NJ 07065-0907 (US)
  • BETT, Andrew, J.
    Rahway, NJ 07065-0907 (US)
  • CHEN, Ling
    Rahway, NJ 07065-0907 (US)
  • KASLOW, David, C.
    Rahway, NJ 07065-0907 (US)
  • SHIVER, John, W.
    Rahway, NJ 07065-0907 (US)
  • TONER, Timothy, J.
    Rahway, NJ 07065-0907 (US)
  • CASIMIRO, Daniel, R.
    Rahway, NJ 07065-0907 (US)

(74) Representative: Horgan, James Michael Frederic et al
Merck & Co., Inc.,Terlings Park,Eastwick Road
Harlow,Essex CM20 2QR
Harlow,Essex CM20 2QR (GB)

   


(54) ENHANCED FIRST GENERATION ADENOVIRUS VACCINES EXPRESSING CODON OPTIMIZED HIV1-GAG, POL, NEF AND MODIFICATIONS