(19)

(11)

EP 1 322 325 A1

(12)

(43) Date of publication: 02.07.2003 Bulletin 2003/27 (21) Application number: 01952780.3 (22) Date of filing: 16.07.2001

(51) International Patent Classification (IPC)7: A61K 39/00, A61K 39/385, A01N 43/40, A01N 43/42 (86) International application number: PCT/US0122/335 (87) International publication number: WO 0200/7761 (31.01.2002 Gazette 2002/05)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 20.07.2000 US 219550 P (71) Applicant: Merck & Co., Inc. Rahway,New Jersey 07065-0907 (US)	(72) Inventor: WAXMAN, Lloyd, H. Rahway, NJ 07065-0907 (US) (74) Representative: Thompson, John Dr. et al Merck & Co., Inc.European Patent DepartmentTerlings ParkEastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)