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(11)

EP 1 322 667 A2

(12)

(88) Date of publication A3: 29.08.2002 (43) Date of publication: 02.07.2003 Bulletin 2003/27 (21) Application number: 01966151.1 (22) Date of filing: 24.08.2001

(51) International Patent Classification (IPC)7: C07K 14/705, C07H 21/04, C12N 15/63, C12N 5/00, C12P 21/02, A61K 38/00, A61K 39/00, A61K 39/395 (86) International application number: PCT/US0126/396 (87) International publication number: WO 0201/8622 (07.03.2002 Gazette 2002/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 25.08.2000 US 227598 P 21.11.2000 US 252131 P 06.07.2001 US 303224 P (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: GENTZ, Reiner, L. Rockville, MD 20850 (US) EBNER, Reinhard Gaithersburg, MD 20878 (US) YU, Guo-Liang Berkeley, CA 94705 (US) RUBEN, Steven, M. Olney, MD 20832 (US) NI, Jian Germantown, MD 20874 (US) FENG, Ping Gaithersburg, MD 20878 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)