(19)

(11)

EP 1 325 134 A2

(12)

(88) Date of publication A3: 30.01.2003 (43) Date of publication: 09.07.2003 Bulletin 2003/28 (21) Application number: 01977540.2 (22) Date of filing: 05.10.2001

(51) International Patent Classification (IPC)7: C12N 15/52, C12N 1/21, C12P 19/62 // (C12P19/62, C12R1:61) (86) International application number: PCT/US0131/255 (87) International publication number: WO 0202/9035 (11.04.2002 Gazette 2002/15)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 05.10.2000 US 238185 P (71) Applicants: REGENTS OF THE UNIVERSITY OF MINNESOTA Minneapolis,Minnesota 55455-2070 (US) Liu, Hung-Wen Austin, TX 78731 (US) Sherman, David H. St. Louis Park, MN 55416 (US) Zhao, Lishan Carlsbad, CA 92009 (US)	(72) Inventors: LIU, Hung-Wen Austin, TX 78731 (US) SHERMAN, David, H. St. Louis Park, MN 55416 (US) ZHAO, Lishan Carlsbad, CA 92009 (US) (74) Representative: Grant, Anne Rosemary  Frank B. Dehn & Co.179 Queen Victoria Street London EC4V 4EL London EC4V 4EL (GB)