(19)

(11)

EP 1 326 852 A1

(12)

(43) Date of publication: 16.07.2003 Bulletin 2003/29 (21) Application number: 00984552.0 (22) Date of filing: 19.10.2000

(51) International Patent Classification (IPC)7: C07D 277/48, C07D 417/12, A61K 31/426, A61K 31/427, A61P 31/18 (86) International application number: PCT/US0041/290 (87) International publication number: WO 0203/2889 (25.04.2002 Gazette 2002/17)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (71) Applicant: Parker Hughes Institute St. Paul, MN 55113 (US)	(72) Inventors: UCKUN, Fatih, M. White Bear Lake, MN 55110 (US) VENKATACHALAM, Taracad, K. Maplewood, MN 55119 (US) (74) Representative: Gallagher, Kirk James et al D Young & Co,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)