(19)

(11)

EP 1 326 863 A2

(12)

(88) Date of publication A3: 19.09.2002 (43) Date of publication: 16.07.2003 Bulletin 2003/29 (21) Application number: 01973346.8 (22) Date of filing: 21.09.2001

(51) International Patent Classification (IPC)7: C07D 471/04, A61K 31/4375, A61K 31/437, A61K 31/407, A61P 25/00, A61K 51/00, C07D 455/02, C07D 487/04 // (C07D471/04, 221:00), C07D209:00,(C07D487/04, 209:00), C07D209:00 (86) International application number: PCT/US0129/624 (87) International publication number: WO 0202/4695 (28.03.2002 Gazette 2002/12)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 22.09.2000 US 234504 P 22.09.2000 US 234505 P (71) Applicant: Ortho McNeil Pharmaceuticals, Inc. Raritan, NJ 08869-0602 (US)

(72) Inventors: APODACA, Richard San Diego, CA 92108 (US) CARRUTHERS, Nicholas, I. Poway, CA 92064 (US) CARSON, John, R. Norristown, PA 19403 (US) CHAI, Wenying San Diego, CA 92126 (US) KWOK, Annette, K. San Diego, CA 92126 (US) LI, Xiaobing Belle Mead, NJ 08502 (US) LOVENBERG, Timothy, W. San Diego, CA 92130 (US) RUDOLPH, Dale, A. San Diego, CA 92126 (US) SHAH, Chandravadan, R. San Diego, CA 92129 (US) (74) Representative: Mercer, Christopher Paul et al Carpmaels & Ransford43, Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)