(19)

(11)

EP 1 326 967 A2

(12)

(88) Date of publication A3: 10.10.2002 (43) Date of publication: 16.07.2003 Bulletin 2003/29 (21) Application number: 01988767.8 (22) Date of filing: 17.10.2001

(51) International Patent Classification (IPC)7: C12N 9/64 (86) International application number: PCT/US0132/596 (87) International publication number: WO 0203/4895 (02.05.2002 Gazette 2002/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 20.10.2000 US 242317 P (71) Applicant: Genetics Institute, LLC Cambridge, MA 02140 (US)

(72) Inventors: RACIE, Lisa, Anne Acton, MA 01720 (US) TWINE, Natalie, Constance Goffstown, NH 03045 (US) AGOSTINO, Michael, John Andover, MA 01810 (US) WOLFMAN, Neil, Michael Dover, MA 02030 (US) MORRIS, Elisabeth, Ann Sherborn, MA 01770 (US) (74) Representative: Ingham, Stephen H. et al Wyeth Pharmaceuticals,Patents & Trade Marks Dept.,Huntercombe Lane South,Taplow Maidenhead,Berks SL6 0PH Maidenhead,Berks SL6 0PH (GB)