| (84) |
Benannte Vertragsstaaten: |
|
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
| (30) |
Priorität: |
07.10.2000 DE 10049673
|
| (43) |
Veröffentlichungstag der Anmeldung: |
|
16.07.2003 Patentblatt 2003/29 |
| (73) |
Patentinhaber: |
|
- Roche Diagnostics GmbH
68305 Mannheim (DE)
Benannte Vertragsstaaten:
DE
- F. HOFFMANN-LA ROCHE AG
4070 Basel (CH)
Benannte Vertragsstaaten:
AT BE CH CY DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
|
|
| (72) |
Erfinder: |
|
- BORDUSA, Frank
06242 Rossbach (DE)
- JAKUBKE, Hans-Dieter
01465 Dresden-Langebrueck (DE)
|
| (56) |
Entgegenhaltungen: :
WO-A-92/02615
|
WO-A-94/18329
|
|
| |
|
|
- XU S ET AL: "Enzymatic coupling of specific peptides at nonspecific ligation sites:
effect of Asp189Glu mutation in trypsin on substrate mimetic-mediated reactions."
JOURNAL OF ORGANIC CHEMISTRY, (2001 MAR 9) 66 (5) 1627-32. JOURNAL CODE: 2985193R.
, 25. Januar 2001 (2001-01-25), XP002218036
- GRUNBERG R ET AL: "Peptide bond formation mediated by substrate mimetics. Structure-guidedoptimization
of trypsin for synthesis." EUROPEAN JOURNAL OF BIOCHEMISTRY, (2000 DEC) 267 (24) 7024-30.
JOURNAL CODE: 0107600. , XP002218037
- CEROVSKY V ET AL: "PROTEASE-CATALYZED FRAGMENT CONDENSATION VIA SUBSTRATE MIMETIC
STRATEGY: A USEFUL COMBINATION OF SOLID-PHASE PEPTIDE SYNTHESIS WITH ENZYMATIC METHODS"
JOURNAL OF PEPTIDE RESEARCH, MUNKSGAARD INTERNATIONAL PUBLISHERS, COPENHAGEN, DK,
Bd. 55, Nr. 4, April 2000 (2000-04), Seiten 325-329, XP000930485 ISSN: 1397-002X
- CEROVSKY V ET AL: "Semisynthesis of Ht31(493--515): involvement of PKA-anchoring proteins
in the regulation of the cAMP-dependent chloride current in heart cells." CHEMBIOCHEM:
A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY. GERMANY 18 AUG 2000, Bd. 1, Nr. 2, 18. August
2000 (2000-08-18), Seiten 126-129, XP002218038 ISSN: 1439-4227
- BORDUSA F: "Nonconventional amide bond formation catalysis: programming enzyme specificity
with substrate mimetics." BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH = REVISTA
BRASILEIRA DE PESQUISAS MEDICAS E BIOLOGICAS / SOCIEDADE BRASILEIRA DE BIOFISICA...
[ET AL.]. BRAZIL MAY 2000, Bd. 33, Nr. 5, Mai 2000 (2000-05), Seiten 469-485, XP008009710
ISSN: 0100-879X
- JAKUBKE H D (REPRINT): "PEPTIDE LIGASES - TOOLS FOR PEPTIDE-SYNTHESIS" ANGEWANDTE
CHEMIE-INTERNATIONAL EDITION IN ENGLISH, (03 FEB 1995) VOL. 34, NO. 2, PP. 175-177.
, XP002218039
- KURTH T ET AL: "Engineering the S1' subsite of trypsin: design of a protease which
cleaves between dibasic residues." BIOCHEMISTRY, (1998 AUG 18) 37 (33) 11434-40. JOURNAL
CODE: 0370623. , XP002218040
- GRÁF ET AL.: "Electrostatic complementarity within the substrate-binding pocket of
trypsin" PROC. NATL. ACAD. SCI., Bd. 85, Juli 1988 (1988-07), Seiten 4961-4965, US
- EVNIN ET AL.: "Substrate specificity of trypsin investigated by using a genetic selection
system" PROC. NATL. ACAD. SCI., Bd. 87, September 1990 (1990-09), Seiten 6659-6663,
US
|
|
