(19)

(11)

EP 1 328 295 A2

(12)

(88) Date of publication A3: 22.05.2003 (43) Date of publication: 23.07.2003 Bulletin 2003/30 (21) Application number: 00954404.0 (22) Date of filing: 25.08.2000

(51) International Patent Classification (IPC)7: A61K 47/48 (86) International application number: PCT/DK0000/471 (87) International publication number: WO 0101/5736 (08.03.2001 Gazette 2001/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 27.08.1999 DK 119799 21.10.1999 US 160782 P 26.11.1999 DK 169199 07.02.2000 DK 200000194 07.03.2000 DK 200000363 14.04.2000 DK 200000642 (71) Applicant: Maxygen Aps 2970 Hoersholm (DK)	(72) Inventors: PEDERSEN, Anders Hjelholt DK-2970 Hoersholm (DK) SCHAMBYE, Hans Thalsgaard DK-2970 Hoersholm (DK) ANDERSEN, Kim Vilbour DK-2970 Hoersholm (DK) BORNAES, Claus DK-2970 Hoersholm (DK) RASMUSSEN, Poul Baad DK-2970 Hoersholm (DK) (74) Representative: Kjerrumgaard, Lars Bo et al Maxygen ApS,Patent Department,Agern Alle 1 2970 Horsholm 2970 Horsholm (DK)