(19)

(11)

EP 1 328 314 A1

(12)

(43) Date of publication: 23.07.2003 Bulletin 2003/30 (21) Application number: 01968923.1 (22) Date of filing: 18.09.2001

(51) International Patent Classification (IPC)7: A61N 1/30 (86) International application number: PCT/US0129/081 (87) International publication number: WO 0202/4273 (28.03.2002 Gazette 2002/12)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.09.2000 US 666989 (71) Applicant: Chiang, Long Y. Acton, MA 01720 (US)	(72) Inventors: CHIANG, Long, Y. Acton, MA 01720 (US) YU, Chi Toronto, Ontario N5T 1K5 (CA) (74) Representative: Hall, Robert Leonard et al Harrison Goddard Foote,Fountain Precinct,Leopold Street Sheffield S1 2QD Sheffield S1 2QD (GB)