(19)
(11) EP 1 328 534 A2

(12)

(88) Date of publication A3:
19.09.2002

(43) Date of publication:
23.07.2003 Bulletin 2003/30

(21) Application number: 01981637.0

(22) Date of filing: 16.10.2001
(51) International Patent Classification (IPC)7C07H 17/08, A61K 31/7048, A61P 31/04
(86) International application number:
PCT/US0132/278
(87) International publication number:
WO 0203/2919 (25.04.2002 Gazette 2002/17)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 16.10.2000 US 240777 P

(71) Applicant: Abbott Laboratories
Abbott Park, IL 60064-6050 (US)

(72) Inventors:
  • MA, Zhenkun
    Gurnee, IL 60031 (US)
  • PHAM, Ly, Tam
    Malden, MA 02148 (US)
  • CLARK, Richard, F.
    Gurnee, IL 60031 (US)
  • ZHANG, Souming
    Brandford, CT 06405 (US)
  • DJURIC, Stevan
    Libertyville, IL 60048 (US)

(74) Representative: Modiano, Guido, Dr.-Ing. et al
Modiano, Josif, Pisanty & Staub,Baaderstrasse 3
80469 München
80469 München (DE)

   


(54) 6-O-SUBSTITUTED ERYTHROMYCIN DERIVATIVES HAVING IMPROVED GASTROINTESTINAL TOLERANCE