(19)

(11)

EP 1 330 441 A2

(12)

(88) Date of publication A3: 11.07.2002 (43) Date of publication: 30.07.2003 Bulletin 2003/31 (21) Application number: 01973190.0 (22) Date of filing: 19.09.2001

(51) International Patent Classification (IPC)7: C07D 235/30, C07D 235/32, A61K 31/4184, A61P 35/00 (86) International application number: PCT/US0129/261 (87) International publication number: WO 0202/6716 (04.04.2002 Gazette 2002/12)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 26.09.2000 US 670169 26.09.2000 US 670168 26.09.2000 US 670170 26.09.2000 US 670166 (71) Applicant: The University of Arizona Foundation Tucson,Arizona 85721 (US)	(72) Inventors: QUADA, James, C,. Jr. San Antonio, TX 78250 (US) AGYIN, Joseph, K. San Antonio, TX 78254 (US) CAMDEN, James, Berger West Chester, OH 45069 (US) (74) Representative: Raynor, John et al W.H. Beck, Greener & Co7 Stone BuildingsLincoln's Inn London WC2A 3SZ London WC2A 3SZ (GB)