(19)
(11) EP 1 330 456 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 2 (W2 B1)

(48) Corrigendum issued on:
08.02.2012 Bulletin 2012/06

(45) Mention of the grant of the patent:
15.06.2011 Bulletin 2011/24

(21) Application number: 01976448.9

(22) Date of filing: 12.10.2001
(51) International Patent Classification (IPC): 
C07D 471/06(2006.01)
A61P 35/00(2006.01)
 A61K 31/4375(2006.01)
(86) International application number:
PCT/GB2001/004557
(87) International publication number:
WO 2002/030932 (18.04.2002 Gazette 2002/16)

(54)

N8,N13 -DISUBSTITUTED QUINO[4,3,2-KL]ACRIDINIUM SALTS AS THERAPEUTIC AGENTS

N8,N13-DISUBSTITUIERTE CHINO[4,3,2,KL]ACRIDINIUM SALZE ALS ARZNEIMITTEL

SELS DE QUINO[4,3,2-KL]ACRIDINIUM N8,N13-DISUBSTITUES UTILISES COMME AGENTS THERAPEUTIQUES

(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

(30) Priority: 12.10.2000 US 239267 P

(43) Date of publication of application:
30.07.2003 Bulletin 2003/31

(73) Proprietor: Cancer Research Technology Limited
London EC1V 4AD (GB)

(72) Inventors:
  • STEVENS, Malcolm F. G., Cancer Research Labs
    Nottingham, Nottinghamshire NG7 2RD (GB)
  • KELLAND, Lloyd Royston, CRC Centre Cancer Therap.
    Sutton, Surrey SM2 5NG (GB)
  • HEALD, Robert Andrew, Cancer Research Labs
    Nottingham, Nottinghamshire NG7 2RD (GB)

(74) Representative: Brasnett, Adrian Hugh et al
Mewburn Ellis LLP 33 Gutter Lane
London EC2V 8AS
London EC2V 8AS (GB)


(56) References cited: : 
   
  • STANSLAS, JOHNSON ET AL: "Antitumor Polycyclic Acridines. 7.Synthesis and Biological Properties of DNA Affinic Tetra- and Pentacyclic Acridines" JOURNAL OF MEDICINAL CHEMISTRY (2000), 43(8), 1563-1572 , XP002201185 cited in the application
  • HAGAN D.J. ET AL: 'Antitumour polycyclic acridines. Part 3.1 A two-step conversion of 9-azidoacridine to 7H-pyrido[4,3,2-kl]acridines by Graebe?Ullmann thermolysis of substituted 9-(1,2,3-triazol-1-yl)acridines' J. CHEM. SOC., PERKIN TRANS. 1 no. 5, 01 January 1998, CHEMICAL SOCIETY. LETCHWORTH, GB, pages 915 - 924, XP001193755
  • HAGAN D.J. ET AL: 'Antitumour polycyclic acridines. Part 1. Synthesis of 7H-pyrido- and 8H-quino-[4,3,2-kl]acridines by Graebe?Ullmann thermolysis of 9-(1,2,3-triazol-1-yl)acridines: application of differential scanning calorimetry to predict optimum cyclisation conditions' J. CHEM. SOC., PERKIN TRANS. 1 01 January 1997, CHEMICAL SOCIETY. LETCHWORTH, GB, pages 2739 - 2746, XP002188534
   
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