(19)

(11)

EP 1 330 473 A2

(12)

(88) Date of publication A3: 13.03.2003 (43) Date of publication: 30.07.2003 Bulletin 2003/31 (21) Application number: 01976527.0 (22) Date of filing: 26.10.2001

(51) International Patent Classification (IPC)7: C07K 14/315, C12N 1/21, C12N 15/63, A61K 39/09, C07K 16/12 (86) International application number: PCT/GB0104/749 (87) International publication number: WO 0203/4773 (02.05.2002 Gazette 2002/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 26.10.2000 GB 0026231 21.11.2000 GB 0028345 02.02.2001 GB 0102666 02.05.2001 US 288118 P (71) Applicant: Imperial College Innovations Limited London SW7 2QA (GB)	(72) Inventors: HOLDEN, David, William,Dept. Infectious Diseases London W12 ONN (GB) BROWN, Jeremy, Stuart London N1 3DJ (GB) (74) Representative: Jappy, John William Graham  Gill Jennings & Every,Broadgate House,7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)