(19)
(11) EP 1 330 515 A1

(12)

(43) Date of publication:
30.07.2003 Bulletin 2003/31

(21) Application number: 00967340.1

(22) Date of filing: 06.10.2000
(51) International Patent Classification (IPC)7C12N 9/00, A61K 39/085, C07K 1/00
(86) International application number:
PCT/US0027/628
(87) International publication number:
WO 0203/1128 (18.04.2002 Gazette 2002/16)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(71) Applicants:
  • SmithKline Beecham Corporation
    Philadelphia, PA 19103 (US)
  • Smithkline Beecham PLC
    Brentford,Middlesex TW8 9EP (GB)

(72) Inventors:
  • DeWOLF, Walter, E., Jr.
    Glenmoore, PA 19343 (US)
  • PAYNE, David, J.
    Phoenixville, PA 19460 (US)
  • SEEFELD, Mark, A.
    Collegeville, PA 19426 (US)
  • WALLIS, Nicola, G.
    Wayne, PA 19087 (US)
  • WEST, Joshua, M.
    Allentown, PA 18104 (US)
  • BRANDT, Martin
    North Wales, PA 19454 (US)
  • KELLER, Paul, M.
    West Chester, PA 19380 (US)
  • PATEL, Arunbhai, H.
    Phoenixville, PA 19460 (US)
  • REED, Shannon, L.
    Norristown, PA 19403 (US)
  • TEW, David, G.
    Harlow,Essex CM19 5AW (GB)

(74) Representative: Adams, Harvey Vaughan John et al
Mathys & Squire,100 Gray's Inn Road
London WC1X 8AL
London WC1X 8AL (GB)

   


(54) METHODS OF AGONIZING AND ANTAGONIZING FABK