(19)

(11)

EP 1 330 654 A2

(12)

(88) Date of publication A3: 01.05.2003 (43) Date of publication: 30.07.2003 Bulletin 2003/31 (21) Application number: 01989278.5 (22) Date of filing: 22.10.2001

(51) International Patent Classification (IPC)7: G01N 33/68, G01N 33/58, G01N 33/532, C07D 405/12 (86) International application number: PCT/US0150/745 (87) International publication number: WO 0204/8717 (20.06.2002 Gazette 2002/25)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 23.10.2000 US 242643 P (71) Applicant: Genetics Institute, LLC Cambridge, MA 02140 (US)	(72) Inventors: QIU, Yongchang Arlington, MA 02476 (US) WANG, Jack, H. Lexington, MA 02420 (US) HEWICK, Rodney, M. Boston, MA 02116 (US) (74) Representative: Lord, Hilton David  MARKS & CLERK,57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)