(19)

(11)

EP 1 332 134 A2

(12)

(88) Date of publication A3: 03.01.2003 (43) Date of publication: 06.08.2003 Bulletin 2003/32 (21) Application number: 01998114.1 (22) Date of filing: 19.10.2001

(51) International Patent Classification (IPC)7: C07D 225/04, A61K 31/415, A61P 27/00, A61P 31/00, A61P 35/00 (86) International application number: PCT/US0150/527 (87) International publication number: WO 0206/0868 (08.08.2002 Gazette 2002/32)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 25.10.2000 US 243236 P (71) Applicant: Merck & Co., Inc. Rahway,New Jersey 07065-0907 (US)	(72) Inventor: BELL, Ian, M. Rahway, NJ 07065-0907 (US) (74) Representative: Thompson, John Dr. et al Merck & Co., Inc.European Patent DepartmentTerlings ParkEastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)